Publications of Patrick Freund

Lebret, A., Frese, S., Lévy, S., Curt, A., Callot, V., Freund, P., & Seif, M. (2025). Spinal cord blood perfusion deficit is associated with clinical impairment after spinal cord injury. Journal of Neurotrauma, 42, 280–291.

Karthik, E. N., Valosek, J., Smith, A. C., Pfyffer, D., Schading-Sassenhausen, S., Farner, L., … Cohen-Adad, J. (2025). SCIseg: Automatic segmentation of intramedullary lesions in spinal cord injury on T2-weighted MRI scans. Radiology: Artificial Intelligence, 7. doi:10.1148/ryai.240005

Weidner, N., Abel, R., Maier, D., Röhl, K., Röhrich, F., Baumberger, M., … Curt, A. (2025). Safety and efficacy of intrathecal antibodies to Nogo-A in patients with acute cervical spinal cord injury: A randomised, double-blind, multicentre, placebo-controlled, phase 2b trial. Lancet Neurology, 24, 42–53.

Schading-Sassenhausen, S., Pfyffer, D., Farner, L., Grillhösl, A., Mach, O., Maier, D., … Freund, P. (2024). Extent of traumatic spinal cord injury is lesion level dependent and predictive of recovery: A multicenter neuroimaging study. Journal of Neurotrauma, 41, 2146–2157.

Pfyffer, D., Smith, A. C., Weber, K. A., Grillhoesl, A., Mach, O., Draganich, C., … Freund, P. (2024). Prognostic value of tissue bridges in cervical spinal cord injury: A longitudinal, multicentre, retrospective cohort study. Lancet Neurology, 23, 816–825.

Emmenegger, T., David, G., Mohammadi, S., Ziegler, G., Callaghan, M. F., Thompson, A., … Freund, P. Temporal dynamics of white and grey matter plasticity during motor skill acquisition: A comparative DTI and qMRI analysis. Cerebral Cortex. Retrieved from http://hdl.handle.net/21.11116/0000-000F-B14C-4

Freund, P., Boller, V., Emmenegger, T. M., Akbar, M., Hupp, M., Pfender, N., … Seif, M. (2024). Quantifying neurodegeneration of the cervical cord and brain in degenerative cervical myelopathy: A multicentre study using quantitativemagnetic resonance imaging. European Journal of Neurology, 31. doi:10.1111/ene.16297

Pfender, N., Jutzeler, C. R., Hubli, M., Scheuren, P. S., Pfyffer, D., Zipser, C. M., … Hupp, M. (2024). Potential thresholds of critically increased cardiac-related spinal cord motion in degenerative cervical myelopathy. Frontiers in Neurology, 15. doi:10.3389/fneur.2024.1411182

Büeler, S., Freund, P., Kessler, T. M., Liechti, M. D., & David, G. (2024). Improved inter-subject alignment of the lumbosacral cord for group-level in vivo gray and white matter assessments: A scan-rescan MRI study at 3T. PLOS ONE, 19. doi:10.1371/journal.pone.0301449

Emmenegger, T. M., Pfyffer, D., Curt, A., Schading‐Sassenhausen, S., Hupp, M., Ashburner, J., … Freund, P. (2024). Longitudinal motor system changes from acute to chronic spinal cord injury. European Journal of Neurology, 31. doi:10.1111/ene.16196

Lebret, A., Lévy, S., Pfender, N., Farshad, M., Altorfer, F. C. S., Callot, V., … Seif, M. (2023). Investigation of perfusion impairment in degenerative cervical myelopathy beyond the site of cord compression. Scientific Reports, 13. doi:10.1038/s41598-023-49896-3

Azzarito, M., Emmenegger, T., Ziegler, G., Huber, E., Grabher, P., Callaghan, M. F., … Freund, P. (2023). Coherent, time-shifted patterns of microstructural plasticity during motor-skill learning. NeuroImage, 274. doi:10.1016/j.neuroimage.2023.120128

Mehnert, U., Walter, M., Leitner, L., Kessler, T. M., Freund, P., Liechti, M. D., & Michels, L. (2023). Abnormal resting-state network presence in females with overactive bladder. Biomedicines, 11. doi:10.3390/biomedicines11061640

Pfyffer, D., Zimmermann, S., Şimşek, K., Kreis, R., Freund, P., & Seif, M. (2023). Magnetic resonance spectroscopy investigation in the right human hippocampus following spinal cord injury. Frontiers in Neurology, 14. doi:10.3389/fneur.2023.1120227

Schading, S., Seif, M., Leutritz, T., Hupp, M., Curt, A., Weiskopf, N., & Freund, P. (2023). Reliability of spinal cord measures based on synthetic T1-weighted MRI derived from multiparametric mapping (MPM). NeuroImage, 271. doi:10.1016/j.neuroimage.2023.120046

Schading, S., David, G., Emmenegger, T. M., Achim, C., Thompson, A., Weiskopf, N., … Freund, P. (2023). Dynamics of progressive degeneration of major spinal pathway following spinal cord injury: A longitudinal study. NeuroImage: Clinical, 37. doi:10.1016/j.nicl.2023.103339

Seif, M., Leutritz, T., Schading, S., Emmengger, T., Curt, A., Weiskopf, N., & Freund, P. (2022). Reliability of multi-parameter mapping (MPM) in the cervical cord: A multi-center multi-vendor quantitative MRI study. NeuroImage, 264. doi:10.1016/j.neuroimage.2022.119751

Büeler, S., Yiannakas, M. C., Damjanovski, Z., Freund, P., Liechti, M. D., & David, G. (2022). Optimized multi-echo gradient-echo magnetic resonance imaging for gray and white matter segmentation in the lumbosacral cord at 3 T. Scientific Reports, 12. doi:10.1038/s41598-022-20395-1

David, G., Vallotton, K., Hupp, M., Curt, A., Freund, P., & Seif, M. (2022). Extent of cord pathology in the lumbosacral enlargement in non-traumatic versus traumatic spinal cord injury. Journal of Neurotrauma, 39, 639–650.

Schading, S., Pohl, H., Gantenbein, A., Luechinger, R., Sandor, P., Riederer, F., … Michels, L. (2021). Tracking tDCS induced grey matter changes in episodic migraine: A randomized controlled trial. The Journal of Headache and Pain, 22. doi:10.1186/s10194-021-01347-y